Insufficient system resources message on inbound email delivery
452 4.3.1 Insufficient system resources error originates from the Microsoft Exchange server due to the server either running out of disk space or free memory.
In Exchange Server, the transport service monitors system resources such as disk space and memory on the transport servers (the Hub Transport and Edge Transport servers), and stops message submission if it is running low on these resources. It continues to deliver existing messages in the queue, and when resource utilization returns to normal, it resumes message submission. This feature is called Back Pressure.
To address this:
- Increase the amount of free space on the Microsoft Exchange server drive
- Reduce the amount of memory being used by all processes